The Perfect Gene Diet, also known as The APO-E Gene Diet is a genetically tailored integrative nutritional plan that focuses on eating the optimal percentages of the big three (carbohydrates, fats, and proteins) food groups for your specific Apo E genotype. This gene plays a key role in our body’s internal environment and influences the development of chronic disease, especially heart and Alzheimer’s disease. It is extremely important eating the right balance of carbohydrates, fats and proteins for your specific Apo E genotype influences the possibility of developing certain diseases, as well as their severity.
Created by Pamela McDonald PNP, FA, WHCNP, a nurse practitioner who currently resides in outside San Francisco, California. The Apo E Gene Diet brings leading-edge genetic science, genomics, DNA testing, and nutritional science together with the optimal Mind-Body-Spirit plan. It focuses on an individual’s genetic recipe and provides a customized dietary and exercise plan based on his or her Apo E gene type. No other program does this.
In addition, the Apo E Gene Diet takes into account the whole person (physical, emotional, and spiritual), helping to create a gene-supportive environment that promotes a healthy life full of well-being.
Apo E Gene Occurrences
The Apo E gene occurs as three variations in humans: Apo E2, Apo E3, and Apo E4.
Since genes come in matching pairs, we each have two of every gene, one from each parent. If you received an Apo E 2 from one parent and an Apo E 3 from the other parent, your genotype would be E 2/3.
Apo E 3/3, is found in approximately 64 percent of the population. It is considered the “neutral” Apo E genotype. Combinations that include either the Apo E 2 or Apo E 4 are considered “alternative” expressions of the more common Apo E 3 pairing. About 25% of the population have one or more of the E 4 genes and 12% have one or more of the E 2 genes. People with an Apo E 2 or 4 process foods differently from the Apo E 3s.
The specific pair of Apo E genes you inherited from your parents greatly influences your predisposition to certain illnesses, including heart disease, vascular dementia, Alzheimer’s disease, Parkinson’s disease, and cancer. For example, persons with the Apo E 4/4 genotype could have up to a 90% chance of developing a chronic illness such as Alzheimer’s disease. Maintaining an optimal diet and lifestyle for your particular Apo E genotype is known as a “gene-supportive environment” (GSE). Doing so can dramatically reduce your risk of developing these chronic illnesses. That’s why the Apo E Gene Diet was created. The goal of the Apo E Gene Diet is disease prevention and a healthier life.
The six possible combinations of Apo E gene pairs are as follows (along with their percentage of occurrence in the General Population):
As each Apo E genotype processes foods differently, one diet does not fit all.
There is a unique optimal combination of carbohydrates, fats, and proteins in the ideal diet for each of the six Apo E genotypes. Creating this optimal balance in your diet provides the foundation for your good health.
Most of the existing dietary recommendations are based on the assumption that one diet is appropriate for everyone. These diets fail to accomplish long-term weight loss or optimal disease prevention because we are not all the same. In reality, diet and exercise recommendations must be individualized, beginning with a person’s genetic foundation.
The Apo E Gene Diet focuses on an individual’s genetic recipe, creating dietary and exercise recommendations for each of the six possible Apo E genotypes.
In addition, the Apo E Gene Diet takes into account the whole person (physical, emotional, mental, and spiritual) in creating a gene-supportive environment that promotes a healthy life, free of chronic illness.
A personalized plan for your Apo E genotype will guide you in choosing the optimal format:
- Fat content – types
- Carbohydrates – types
- Protein – types
- Caloric content
- Amount & kind of exercise
- Balance of stress & relaxation
- Mental & emotional
- Spiritual component